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Christine E Canman Selected Research

Neoplasms (Cancer)

1/2021Which Holds the Key to BRCAness: Inability to Repair the Break, Protect the Fork, or Prevent the Gap?
1/2021Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer.
12/2018Replication Stress: An Achilles' Heel of Glioma Cancer Stem-like Cells.
3/2014PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer.
3/2014A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.
12/2013Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity.
6/2012DNA polymerase ΞΆ is a major determinant of resistance to platinum-based chemotherapeutic agents.
6/2010Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.
1/2009Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.
12/2006Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.

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Christine E Canman Research Topics

Disease

10Neoplasms (Cancer)
01/2021 - 12/2006
5Ataxia Telangiectasia (Louis Bar Syndrome)
01/2021 - 06/2004
4Pancreatic Neoplasms (Pancreatic Cancer)
01/2021 - 01/2009
3Genomic Instability
11/2014 - 01/2012
3Fanconi Anemia (Fanconi's Anemia)
12/2012 - 03/2009
1Glioblastoma (Glioblastoma Multiforme)
12/2018
1Prostatic Neoplasms (Prostate Cancer)
03/2014
1Chromosome Aberrations (Chromosome Abnormalities)
03/2010
1Psoriasis (Pustulosis Palmaris et Plantaris)
03/2009
1Xeroderma Pigmentosum (Kaposi's Disease)
03/2009

Drug/Important Bio-Agent (IBA)

7DNA (Deoxyribonucleic Acid)IBA
01/2021 - 03/2009
4Phosphotransferases (Kinase)IBA
12/2018 - 06/2004
3DNA-Directed DNA Polymerase (Polymerases, DNA)IBA
11/2014 - 12/2012
2Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2021 - 12/2018
21,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
03/2014 - 01/2012
2Proteins (Proteins, Gene)FDA Link
03/2014 - 03/2014
2Cisplatin (Platino)FDA LinkGeneric
03/2014 - 03/2010
2Proliferating Cell Nuclear Antigen (PCNA)IBA
03/2014 - 03/2010
2GemcitabineFDA Link
06/2010 - 01/2009
1ceralasertibIBA
01/2021
1Poly (ADP-Ribose) Polymerase-1IBA
01/2021
1olaparibIBA
01/2021
1Temozolomide (Temodar)FDA LinkGeneric
12/2018
1MAP-kinase-activated kinase 2IBA
03/2014
1Long Noncoding RNAIBA
03/2014
1NucleosidesIBA
12/2013
1Pharmaceutical PreparationsIBA
12/2013
1Ganciclovir (Cytovene)FDA LinkGeneric
12/2013
1DDTIBA
03/2013
1amminedichloro(2- methylpyridine)platinum(II) (ZD0473)IBA
06/2012
1satraplatin (JM 216)IBA
06/2012
1Oxaliplatin (Eloxatin)FDA LinkGeneric
06/2012
1Radiation-Sensitizing AgentsIBA
06/2010
13- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamideIBA
06/2010
1Mitomycin (Mitomycin-C)FDA LinkGeneric
03/2010
1Ficusin (Psoralen)IBA
03/2009
1Protein Kinases (Protein Kinase)IBA
01/2009
1Checkpoint Kinase 1IBA
01/2009
17-hydroxystaurosporine (UCN 01)IBA
01/2009
1Mitogen-Activated Protein Kinase 3IBA
12/2006
1Mitogen-Activated Protein Kinase PhosphatasesIBA
12/2006
1ChromatinIBA
06/2004

Therapy/Procedure

2Therapeutics
01/2021 - 12/2018